992-Organ Specific Autoimmune Diseases

Course # DL-992: Organ Specific Autoimmune Diseases

by Paula J. D’Amore, Ph.D., D (AMBLI) - Assistant Professor, Division of Health Sciences - California State University, Dominguez Hills

Approved for 1.0 CE
Level of Difficulty: Intermediate


Autoimmune Diseases

Autoimmune diseases are generally divided into two categories: organ-specific and systemic. In systemic autoimmune diseases such as systemic lupus erythematosus (SLE), scleroderma, and rheumatoid arthritis (RA), an immune response is directed against one or several self antigens present throughout the body. Organ-specific autoimmune disorders usually target an antigen(s) present on a single organ or tissue and an immune response is limited to that specific organ. Within this group, the endocrine system appears to be a common target for autoimmune disease and will be the primary focus of this article.


After completing this course the participant will be able to:

1. Compare hypothyroidism and hyperthyroidism and discuss the two related autoimmune diseases.

2. Identify and describe the autoantibodies associated with each autoimmune disease discussed.

3. Describe Autoimmune Polyglandular Syndromes 1 and 2.

4. Identify and discuss the non-HLA genes that contribute to autoimmune diseases.

5. Discuss the development of Pernicious Anemia in Autoimmune Polyglandular Syndromes.

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